EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF Solanum Nigrum IN ALLOXAN INDUCED DIABETIC RATS
نویسنده
چکیده
Objectives: Evaluation of antihyperglycemic activity of aqueous extract of leaves of Solanum nigrum (AELSN) in Alloxan induced diabetic rats. Comparison of antihyperglycemic activity of aqueous extract of leaves of Solanum nigrum with standard drug Glimepiride. Methodology: 200-250 g of Wistar rats of either sex were divided into 4 groups (n=6). Group l is normal control (received 0.5ml normal saline), Group ll is diabetic control (received 0.5ml normal saline), Group lll is standard group (received glimepiride 0.1mg/Kg b.w.), Group lV is AELSN group (received AELSN 400mg/kg b.w.). Diabetes was induced by using Alloxal monohydrate 120mg/Kg b.w. intraperitoneally. All the animals received the respective drug for 21 days. Fasting blood glucose was measured by using the glucometer on 0 day, 1 day, 7 day, 14 day, & 21 day. Results: Aqueous extract of leaves of Solanum nigrum Linn showed significant fall in fasting blood sugar (p value < 0.01) at 21 day, but less than the standard drug Glimepiride (p value < 0.001). This study can be recommended for further evaluation.
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